← All Positions
Posted May 17, 2026

Senior Clinical Sciences Manager

Apply Now
Join Immatics and shape the future of cancer immunotherapy; one patient at a time!     Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.    Why Join Us?  Innovative Environment: Help to pioneer advancements in cancer immunotherapy.  Collaborative Culture: Be part of a diverse team dedicated to your professional growth.  Global Impact: Contribute to therapies that make a lasting impact on patients globally.    Role Overview  We are seeking a Senior Clinical Sciences Manager to support the execution of our clinical trials, including the SUPRAME (IMA203-301) study. The Senior Manager will be responsible for supporting patient journey navigation, primarily for U.S. sites, and updating patient-facing and clinical trial materials. In addition, this role will contribute to protocol development, conduct literature research, support trial outcome reporting, and deliver training to internal and external stakeholders.     Reports to: Director, Clinical Sciences  Location: Fully Remote  Salary Range: $155,000 – 175,000    Basic Qualifications:  Bachelor’s degree in biology, pharmacy, or a related scientific field   7+ years of experience conducting literature research using clinical and medical databases   Demonstrated experience supporting clinical trial activities, including protocol and patient-facing materials   Experience training site staff or internal teams on clinical trial protocols and materials    Preferred Qualifications: Master’s degree in biology, pharmacy, or a related scientific field   Experience supporting regulatory documentation (e.g., IRB submissions, RFIs)   Experience working in oncology or cell therapy clinical development   Advanced ability to translate complex scientific data into clear, actionable insights and presentations   Experience working cross-functionally in a global clinical trial environment    In this role you will:   Serve as a key point of contact for clinical trial protocol and patient-facing material inquiries from sites and internal teams   Support patient journey navigation, including proactive management of screening activities   Contribute to authoring and updating clinical trial documents, including protocols, reports, and investigator materials   Support preparation of responses for IRBs and regulatory authorities   Deliver site training on clinical trial protocols and patient-facing materials (e.g., SIVs)   Conduct literature research and develop presentations to support clinical activities   Maintain accurate eTMF documentation and filing    Travel required: up to 20% travel required, domestically and internationally.   Qualified candidates will participate in a structured interview process, which includes:  An initial recruiter phone screen (conducted via video)  A recruiter-facilitated introduction and interview with the hiring leader and key stakeholders (via video)  A final-stage interview, which may include an in-person meeting at our U.S. Headquarters in Houston, TX  Work authorization/security clearance requirements:   Legal eligibility to work in the United States is required. Immatics participates in E-Verify and all new employees will be subject to the Department of Homeland Security requirements for employment    Affirmative Action/EEO statement:    Immatics is an equal opportunity employer. All employment decisions including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs.   What do we offer?   At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics:     Comprehensive Benefits:   Competitive rates for Health, Dental, and Vision Insurance  4 weeks of vacation, granted up front each year and prorated for first and last year of employment.  12 company paid holidays  7 days of sick time  100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars   100% employer-paid short- and long-Term disability coverage   401(k) with immediate eligibility and company match…  The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.  Partially paid parental leave for eligible employees.  Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance. Apply To This Job